Laboratory of System Neuroimmunology
Immunity in Alzheimer’s Disease:
from molecular mechanisms to therapeutic strategies
Immunity in Alzheimer’s Disease:
from molecular mechanisms to therapeutic strategies
Chen lab focuses on understanding the brain-immune interactions in health, aging, and disease.
The major research directions in Chen lab are:
■ Decoding the immune responses in Alzheimer’s disease and therapeutics development
■ Deciphering brain-immune interface and brain-body interaction
■ Understanding neuronal plasticity throughout AD progression
PRINCIPAL INVESTIGATOR
Dr. Xiaoying Chen is an Associate Professor and Principal Investigator at the Institute for Immunology and the IDG/McGovern Institute for Brain Research at Tsinghua University. She is also affiliated with the Tsinghua-Peking Center for Life Sciences. In 2025, she founded the System Neuroimmunology Laboratory at Tsinghua University. Her research focuses on understanding the brain-immune communication across health, aging, and disease.
Dr. Xiaoying Chen has contributed significant insights into understanding neuronal plasticity during development, learning activities, and neuron-immune interactions in neurodegenerative disease. She has received a number of honors and awards, including the Jeffrey L. Morby Prize for Best Research in Alzheimer’s Disease from Cure Alzheimer’s Fund (2024), the Early Career Achievement Award from Alzheimer’s Association (2023), the Career Development Award from the Society for Neuroscience (2023), the Coins for Alzheimer’s Research Trust from Rotary Foundation (2023), the O’Leary Prize for Best Neuroscience Research at Washington University (2022), the Poletsky Award for Alzheimer’s Disease Research from Washington University (2022), and the Tau Consortium Fellowship from Rainwater Charitable Foundation (2019).
She is a member of Society for Neuroscience, Alzheimer’s Association, American Society for Neurochemistry, American Neurological Association and International Society for Molecular Neurodegeneration. Dr. Chen has reviewed papers for journals, including Immunity, Nature Neuroscience, Neuron, Alzheimer's & Dementia, Science Advances, Cell Reports, Molecular Neurodegeneration, and Journal of Clinical Investigation.
Fundings